APOD and Alzheimer disease: ApoD might be a neuroprotective, antioxidant, and anti-inflammatory molecule, as indicated by its increased presence in the hippocampus, prefrontal cortex, temporal cortex, entorhinal cortex, and neurons/glial cells affected by neurofibrillary tangles, although the number is lower in diffuse plaques as compared to mature ones in AD subjects [3,4,6,76,82,95,105,106].