SPARC and kidney disorder: Except for SELL and SPARC, the other 12 genes belong to the defense response biological process (FDR < 0.0001), and CFP, SERPING1, C3, SLPI, CCL2, and CXCL10 are involved in the humoral immune response process (FDR < 0.0001) which may suggest the impaired humoral memory responses to early-present antigens in kidney disease [32].