SPP1 and chronic kidney disease: By integrating the performance of ROC in different paired comparisons and clinical correlation analyses, ALCAM (top AUC in LN vs. HC and strongly correlated with uPCR), CD163 (top AUC in LN-Flare vs. LN-Remission and strongly correlated with uPCR and uRBC), SERPING1-ICx (top AUC in LN vs. CKD and strongly correlated with AI and uRBC), and SPP1 (strongly correlated with SLEDAI, CI, and sCreatinine) were identified as candidates for an LN urine biomarker panel.