A limited number of studies have reported increased urine levels of N-acetyl-β-d-glucosaminidase, cathepsin B, albumin, and β2 microglubulin, which are markers of glomerular or tubular damage, in addition to a decrease in renal volume in newborns of mothers with GDM [8,9,23,24]. The gene discussed is CTSB; the disease is gestational diabetes.