The mechanisms behind pomegranate fruit’s anti-cancer activity include the induction of apoptosis, the arrest of the cell cycle, and the modulation of key signaling pathways, including nuclear factor-erythroid factor 2-related factor 2 (Nrf2), nuclear factor kappa B (NF-kB), and mitogen-activated protein kinase (MAPK) [166]. This evidence concerns the gene NFE2L2 and cancer.