The nucleosome remodeling and deacetylase (NuRD) complex, which includes proteins such as histone deacetylase 1 (HDAC1) and 2 (HDAC2), is another ATP-dependent chromatin remodeler complex whose impaired function leads to developmental delay, IDs, and ASDs, among other disorders [21,22,23,24]. This evidence concerns the gene HDAC1 and Global developmental delay.