In addition to its role in neurodevelopment, PHF14 also forms part of another subcomplex that includes KMT2A, PHF5A, HMG20A, and RAI1, a subcomplex that epigenetically regulates pancreatic cancer stem cells through KMT2A’s methyltransferase activity [212]. This evidence concerns the gene KMT2A and familial pancreatic carcinoma.