This study aimed to determine whether the circ_0079593, sponging miR-516b-5p, could modify the regulation of two melanoma-associated genes, Melanoma Cell Adhesion Molecule (MCAM) and Chromatin Assembly Factor 1 Subunit B (CHAF1B) in two different types of melanoma metastasis cell lines. The gene discussed is CHAF1B; the disease is melanoma.