Individual 9 in Reis et al. (2023) [11] with a ~4.08 Mb deletion including HCCS had a clinical diagnosis of Axenfeld–Rieger syndrome with bilateral congenital glaucoma, polycoria, microphthalmia (right smaller than left), corneal opacity with failed corneal transplant in adulthood, and small congenital cataracts. Here, HCCS is linked to early-onset non-syndromic cataract.