However, many upregulated tumor-suppressor genes have been discovered, for example, integrin alpha7 (ITGA7), which is known to induce apoptosis in prostate cancer cells in vitro and in vivo [22] by interacting with the high-temperature requirement A2 (HtrA2), which mediates cell death in cancer cells [22]. Here, HTRA2 is linked to Familial prostate cancer.