On the other hand, DAG activates the Golgi-resident protein kinase D (PKD), promoting vesicle transport and increasing the release of ECM components such as fibronectin (FN), laminin V, and laminin B1, facilitating ECM deposition and remodeling, affecting mechanosignaling and stromal cell activation within the tumor microenvironment, thereby enhancing tumor growth, metastasis, and colonization [79,80]. This evidence concerns the gene PRKD1 and neoplasm.