Altered APA patterns have been observed in several neurodegenerative diseases [127,128], where the changes in APA profiles are restricted to a limited set of genes, with only a few genes affected, primarily those linked to protein turnover and mitochondrial function, such as ubiquitin protein ligase E3 component N-recognin 1 (UBR1) and oxoglutarate dehydrogenase L (OGDHL) [129]. This evidence concerns the gene OGDHL and neurodegenerative disease.