APP and Alzheimer disease: Several studies have been conducted to understand the molecular foundations of neurodegenerative processes [78], for example, a large-scale dysregulation of histone acetylation and chromatin remodeling due to tau pathology in the human prefrontal cortex [351], which is linked to memory decline and AD [352], lysine H3K27 acetylation (H3K27ac) in the entorhinal cortex, and differentially acetylated peaks that were enriched in disease-related biological pathways, including the genes involved in the progression of amyloid-β and tau pathology (e.g., APP, PSEN1, PSEN2, and MAPT) [353].