Key differentials include enzyme deficiencies in glycolysis or red blood cell metabolism (e.g., pyruvate kinase deficiency, glucose-6-phosphate dehydrogenase (G6PD) deficiency, and phosphoglucose and triosephosphate isomerase deficiency), hemoglobinopathies, membrane disorders, autoimmune hemolytic anemia, and drug-induced hemolysis. This evidence concerns the gene G6PD and hemoglobinopathy.