Furthermore, insights from pathways such as ‘Proteins with Altered Expression in Cancer Metabolic Reprogramming’, ‘Metabolic effects of oncogenes and Tumor suppressors in cancer cells’ from ‘Elsevier Pathway Collection’, ‘Control of Gene Expression by Vitamin D Receptor Homo sapiens h vdrPathway’, and ‘Inhibition of Cellular Proliferation by Gleevec Homo sapiens h Gleevec pathway’ in ‘BioCarta 2016’ indicate differences in genes associated with tumor growth inhibition between methionine-dependent and methionine-independent melanoma cells. The gene discussed is VDR; the disease is cancer.