The ISCA1 protein was significantly upregulated in normal tissues of BRCA, GBM, LIHC, and PAAD patients, whereas it was downregulated in normal tissues of COAD, HNSC, LUAD, LUSC, OV, and UCEC patients (Supplementary Figure S1C). The gene discussed is ISCA1; the disease is pancreatic adenocarcinoma.