When we transfected MCF-7 and FaDu cells with WT-ALOX12 and WT-FKBP5 genes, the recreated overexpression of ALOX12 and FKBP5 led to the induction of cellular death, inhibition of cellular invasion abilities, and strong inhibition of xenograft tumor growth. The gene discussed is ALOX12; the disease is neoplasm.