IL1B and neoplasm: Having only one A2 allele, however, reduces the possibility of the presence of the T allele; however, it is necessary to perform genotyping of the IL-1β variant to confirm this theory, since other publications have reported the association of the haplotypes of these two members of the IL-1 family with CRC, concluding that haplotypes formed with alleles associated with increased production of IL-1β, such as IL-1RN decrease alleles (≥4 repeats), are associated with neoplasms [30].