JCAD and Alzheimer disease: Several pleiotropic loci have been identified between AD and CAD [84,98,174]; for example, the genes ARHGAP26 [84,99], FMNL2 [175], TMEM43 [91], ABI3 [59], and KIAA1462 [67,100,176,177] have all exhibited evidence of AD and CVD or vasculature involvement.