Previous GWASs have demonstrated the association of the studied polymorphic loci ADCY3 rs1167627272, CLOCK rs1801260, FTO rs1421085, GPR61 rs41279738, RP11-775H9.2 rs1296328, SLC22A3 rs9364554, and TFAP2B rs734597 with obesity-related phenotypes [25,26,27]. This evidence concerns the gene ADCY3 and obesity due to melanocortin 4 receptor deficiency.