The first model included genetic variants known to be associated with obesity—specifically, ADCY3 rs11676272, CLOCK rs1801260, GPR61 rs41279738, FTO rs1421085, RP11-775H9.2 rs1296328, SLC22A3 rs9364554, and TFAP2B rs734597—and explained 8.3% of the variance in BMI. The gene discussed is SLC22A3; the disease is obesity due to melanocortin 4 receptor deficiency.