NLRP3 and acute respiratory distress syndrome: Finally, nano-chemically modified tetracycline-3 (nCMT-3), when administered to mice before an LPS-induced acute lung injury (ALI), reduced histologic lung injury (polymorphonuclear neutrophil infiltration, alveolar thickening, edema, and consolidation), MMP-2 and -9 levels and activity, and NLRP-3 protein and activated caspase-1 levels in lung tissue.