The amyloid plaque load observed in older male mice, as reported by Guil-herme et al. [54]; Kaur et al. [55]; Mezö et al. [10]; and Minter et al. [5], was reduced through the administration of a combination of antibiotics starting at an early age to three distinct amyloid mouse models of AD (APP/PS1, 5xFAD, and AppNL-G-F). This evidence concerns the gene APP and amyloidosis.