In BD, the purinergic system appears dysregulated [118] and involves increased activity in oxidative stress-related pathways like SIRT-1, AMPK, PKA, PKC, GSK, and inositol triphosphate, as well as increased levels of antiapoptotic proteins, such as Bcl-2, PI3K, mTOR, Akt, and uric acid. Here, SIRT1 is linked to Behcet disease.