After SITG treatment, AChE levels were significantly reduced in the T2DM + SITG10 (4.671 ± 0.160; p < 0.001) and T2DM + SITG30 (4.433 ± 0.183; p < 0.001) groups in diabetes rats, restoring them to levels comparable to control animals. The gene discussed is ACHE; the disease is type 2 diabetes mellitus.