The data have resulted in some intriguing findings that merit further investigation including: (1) the specificity of ANA12 on AKT and the differential effect of ANA12 on BDNF in AD mice; (2) the behavioral dissociation between rTMS and TrkB antagonism; and (3) the relationship between BDNF and other factors in hypoactive behavior. This evidence concerns the gene NTRK2 and Alzheimer disease.