RUNX3 and myocardial infarction: As compared to 4-OH-TAM-treated miR-150fl/fl hearts, we found that 4-OH-TAM-treated MF-specific miR-150 cKO hearts have increased cleaved-caspase 3-positive cells as well as increased expression of apoptotic Bak1 (Figure 4A–C) and fibrotic markers such as Ctgf, Snail, and Runx3 at baseline (Figure 7A–C), indicating that miR-150 may be deleted in 4-OH-TAM-treated MF-specific miR-150 cKO without MI, though to a lesser extent.