The lactylation of Ikaros family zinc finger 1 (IKZF1) at lysine 164, for example, enhances the differentiation of Th17 cells by upregulating the expression of Th17-associated genes, including Runx1, Tlr4, IL-2, and IL-4, further contributing to the suppression of anti-tumor immunity [68]. Here, IKZF1 is linked to neoplasm.