PRRT2 and irritable bowel syndrome: Recently, clinical and animal studies have shown that TRPV1 is involved in the pathogenesis of IBS visceral hypersensitivity and that changes in the abundance of Clostridium sensu stricto 1 and increased sodium butyrate promote visceral hypersensitivity in IBS models through the lincRNA-01028-PKC-TRPV1 pathway [216].