Numerous studies have associated all hub genes identified from downregulated DEGs with Alzheimer’s disease (AD) and other neurological conditions like dementia and Parkinson’s disease, e.g., NR4A3, which is involved in the regulation of the immune system or MEF2D, which has a neuroprotective role [34,35,36,37,38,39,40,41,42]. The gene discussed is MEF2D; the disease is early-onset autosomal dominant Alzheimer disease.