The relevant upregulated hub genes were CD2, CDC25A, CKS2, ESPL1, KIF20A, LCK, PRKACG, S100A7, SPRR2G and SPRR3. No AD-related information is available for the ESPL1, KIF20A, SPRR2G, and SPRR3 genes; however, they are associated with different types of cancer [52,53,54,55]. This evidence concerns the gene ESPL1 and cancer.