Numerous studies have associated all hub genes identified from downregulated DEGs with Alzheimer’s disease (AD) and other neurological conditions like dementia and Parkinson’s disease, e.g., NR4A3, which is involved in the regulation of the immune system or MEF2D, which has a neuroprotective role [34,35,36,37,38,39,40,41,42]. Here, NR4A3 is linked to Alzheimer disease.