Some studies have shown that by detecting the changes in plasma methylation levels of BMPR1A and PLAC8 genes in patients with and without recurrence of hepatocellular carcinoma and comparing them with the traditional tumor marker AFP in predicting the recurrence of hepatocellular carcinoma, the results indicated that the sensitivity and specificity of the combined detection of BMPR1A and PLAC8 methylation in predicting the recurrence of hepatocellular carcinoma were 66.7% and 88.9%. This evidence concerns the gene PLAC8 and hepatocellular carcinoma.