Hulbert [67] found that the combination of three genes, SOX17, TAC1, and HOXA7, could differentiate between individuals with lung cancer and those with benign nodules, and the sensitivity of their individual genes was only about 70%, while the sensitivity of the three genes for the combined detection of lung cancer reached 93% and 98% in blood and sputum, respectively. Here, TAC1 is linked to lung cancer.