Integrins seem to act in the mechanical stimulation of insulin signaling through a subgroup of integrin (P2) that directly impacts insulin sensitization, leading to an imbalance in glycemia and an inflammatory process through the infiltration of leukocytes in adipose tissue, which highlights the systemic inflammatory state present in patients with any degree of obesity [8]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.