IL18 and coronary artery disorder: Concerning IL-18 polymorphisms, two studies conducted by Yang et al. and Zheng et al. associated the appearance of the mutant allele of rs187238 and rs1946518 with higher risks of CAD [55,56], while Lian et al. showed a significantly reduced risk of CAD was correlated with rs187238 in the heterozygous model and dominant model [57].