IL18 and coronary artery disorder: There was no heterogeneity displayed among the overall analyses of associations between rs187238 and rs1946519 of IL-18 and susceptibility to CAD (Table 3), while significant heterogeneity (p < 0.001, I2 ranged from 68 to 76%; Figure 4) was detected in the four genetic models of IL-18 rs1946518.