Previous studies initially highlighted the function of interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) in CAD, followed by a broad focus on other cytokines such as interleukin-8 (IL-8), interleukin-18 (IL-18) and interleukin-16 (IL-16). The gene discussed is TNF; the disease is coronary artery disorder.