Higher plasma FGF23 levels are associated with phosphate-wasting disorders such as autosomal dominant hypophosphatemic rickets (ADHR) [292], bone cancers (e.g., tumor-induced osteomalacia (TIO)) [293], kidney disorders (e.g., chronic kidney disease, acute kidney injury, diabetic nephropathy) [290], heart conditions (coronary heart disease, atherosclerosis, ischemia-reperfusion), and inflammation [5]. The gene discussed is FGF23; the disease is autosomal dominant hypophosphatemic rickets.