Further, dysregulated FGF21 levels are affiliated with certain metabolic diseases such as liver diseases (e.g., nonalcoholic fatty liver disease [281] and nonalcoholic steatohepatitis [282], liver fibrosis [283]), obesity [282], diabetes [283], cardiovascular diseases (e.g., atherosclerosis [284]), and cancer [276]. Here, FGF21 is linked to metabolic dysfunction-associated steatotic liver disease.