In melanoma, FGF5-MAPK-NFAT signaling resulted in enhanced invasion and clonogenicity, worsening the disease outcome [173], whereas in nasopharyngeal carcinoma, FGF5-FGFR2 interaction ensued Keap1, Nrf2, and HO-1 activation in cancer-associated fibroblasts, leading to decreased sensitivity to cisplatin-based chemotherapy, attenuating its efficacy [174]. Here, FGF5 is linked to cancer.