Meanwhile, patients hospitalized with HFpEF often have low NT-proBNP levels, which was associated with age < 65 years, ischemic etiology, obesity, higher LVEF, eGFR > 80 mL/kg/1.73 m2, and a lower NYHA class, whereas chronic kidney disease and diabetes mellitus were associated with elevated levels of NT-proBNP [9,38,39]. The gene discussed is NPPB; the disease is diabetes mellitus.