HDAC3 and pemphigus foliaceus: The activation of the TGF-β1/Smad3 signaling pathway was associated with the transcription of HDAC3, and the administration of RGFP966 (1, Figure 2), a selective inhibitor of HDAC3 (IC50 = 80 nM) [21], was able to protect mice from bleomycin-induced PF and EMT [20].