PLAU and Anxiety: In the OF test, hippocampal uPA mRNA expression was significantly negatively correlated with the number of fecal boli (r(37) = −0.365, p = 0.026; Figure 7C), while a positive correlation was observed between uPA mRNA and the number of rearing episodes (r(37) = 0.415, p = 0.011; Figure 7D), indicating that higher uPA levels were linked to reduced anxiety-like behaviors.