PSPHP1 and Alzheimer disease: For instance, Cai and coworkers used MS-based proteomics to profile the plasma exosomal proteome in patients with AD and reported that plasma exosomal proteins (A0A0G2JRQ6, C1QC, CO9, GP1BB, and RSU1) act as a novel candidate biomarker to differentiate patients with AD from healthy individuals.