In a HER2+ tumor sample (patient BC05), the single MEST SNP (rs10863) reported as imprinted in healthy bulk breast tissue exhibited significant (FDR < 0.05) LOI in no less than 9 out of the 12 (75%) tumor cells meeting the filtering criteria for this patient (Figure 5A, Table 2, Supplementary Tables S5 and S8). The gene discussed is ERBB2; the disease is neoplasm.