A large number of genes (Supplementary Table S4), including well-known imprinted ones such as MEST, H19, HM13, MEG3, PEG10, PEG3, SNHG14, PWAR6 and SNRPN, featured SNPs with clear biallelic expression in multiple cancer cells, which is compatible with the basic definition of LOI. The gene discussed is MEG3; the disease is cancer.