Additionally, PAK1 plays a crucial role in cancer-related angiogenesis, proliferation, and vascular remodeling; the overexpression or nuclear translocation of activated PAK1 confers a proangiogenic function to mucinous fibrosarcoma, highlighting the vulnerable PAK1/STAT5B/CSF2 regulatory axis [5,16,25,75]. The gene discussed is PAK1; the disease is cancer.