CDH1 and neoplasm: However, while Wang et al. reported E-cadherin suppression to favor tumor metastasis, in this study, Notch1 and E-cadherin expression levels were shown to positively correlate in human HCC tissues and promote invasiveness, revealing the complexity of the Notch1/Snail1/E-cadherin axis, as already highlighted by other works [49,50,61].