We have previously shown that LOX is upregulated in the EoE esophagus, specifically in the esophageal epithelium [25,45], and that EoE-related cytokines, including TNFa, TGFb, and IL-13, all increase the expression of LOX in the epithelium [45]. The gene discussed is TGFB1; the disease is eosinophilic esophagitis.