In a mouse model of asthma, Li et al. showed that activation of RAGE by HMGB1 in DCs resulted in the differentiation of naive T cells into type 2 and 17 helper T cells (Th2 and Th17)) through the activation of the RAGE/NF-κB signal pathway in the T cells (Figure 3) [54]. The gene discussed is HMGB1; the disease is asthma.