IGF1 and juvenile idiopathic arthritis: This analysis of the serum levels of CS/DS and IGF-1 (Figure 2a) elicited the existence of significant negative relationships between these parameters in the group of children with treated JIA (r = −0.2929, p = 0.05) and especially, in untreated patients with this disease (r = −0.580, p < 0.0001).