Sandra Ortiz-Cuaran et al. reported that the EMT-inducer ZEB1 induces the immunosuppressive environment in NSCLC by impacting CD70 expression and fostering increased activity of the CD70 promoter, a regulatory ligand from the tumor necrosis factor ligand family, which is associated with decreased CD3+ and CD8+ T cell infiltration and increased T cell exhaustion [6]. The gene discussed is CD8A; the disease is non-small cell lung carcinoma.