Thus, tumor cells undergoing EMT disturb the cancer-immunity cycle by inhibiting the infiltration of functional T cells or inducing the infiltration of immunosuppressive cells, such as polymorphonuclear MDSCs, myeloid cells, mast cells, and natural CD4+ CD25-Tregs, but not necessarily accompanied by reduced tumor infiltration of immune cells, called immune rejection and immune bias mainly [62]. The gene discussed is CD4; the disease is neoplasm.