Twist1, another important EMT-TF, regulated the TME via immune infiltration in 44 types of cancer, including NSCLC, in the study by Wang et al. The findings of these studies indicate that fibroblasts, which exhibit the potential to suppress and compartmentalize CD8+ T cells and other immunocytes, are one of the most important infiltrating cells indicating poor prognosis [83]. Here, CD8A is linked to non-small cell lung carcinoma.