The anti-apoptotic role of GLP-1 in various cell types is already well documented [2], with GLP-2 previously demonstrated to protect against streptozotocin-induced DNA damage in beta-cells [19], as well as dextran sulphate-induced colitis and obesity-related neuroinflammation in mice [31,32]. Here, GCG is linked to obesity due to melanocortin 4 receptor deficiency.