While the majority of MCI donors in the MIT ROSMAP Multiomics dataset presented neuropathology falling in Braak stages 1 and 2, deviating from the typical distribution where most MCI patients fall between stages 3–4 [67,68], the significant decline in HNP neuron abundance among MCI brains in this dataset further substantiates the early alteration of ADNP expressions associated with AD progression. Here, ADNP is linked to Alzheimer disease.