ADNP and Alzheimer disease: As expected, we found that only the hippocampus, frontal cortex, anterior cingulate gyrus, and amygdala—all of which are brain regions affected by early AD [52,53,54,55,56,57]—showed a significant decrease of ADNP transcription during aging among the 11 brain regions selected from GTEx (Table 1; Figure 4D) [3,19,35].