These datasets included: (1) the progression of cognitive impairment from normal aging to mild cognitive impairment (MCI) and finally to AD (the MIT ROSMAP Multiomics dataset) [21,51], (2) the advancement of AD neuropathology through different Braak stages (the Leng dataset) [26,33], and (3) the effects of aging, a major risk factor for AD, on ADNP expression in various brain regions (the GTEx v8 dataset) (Figure 4A) [28]. This evidence concerns the gene ADNP and Cognitive impairment.