Observations on diet-induced obese murine models of pancreatic ductal adenocarcinoma (PDAC) have revealed that obesity is associated with accelerated tumor growth and impaired chemotherapy effectiveness, due to the recruitment of tumor-associated neutrophils (TANs) by adipocyte-secreted IL1β, resulting from overactivation of pancreatic stellate cells [154]. This evidence concerns the gene IL1B and neoplasm.