This signaling involves molecules that favor: (i) tumor expansion, such as granulocyte colony-stimulating factor (G-CSF), granulocyte–macrophage colony-stimulating factor (GM-CSF), and macrophage colony-stimulating factor (M-CSF); (ii) tumor maturation, such as IL-1, IL-4, IL-6, IL-13, and TNF; and (iii) recruitment into the TME, such as IL-8, CCL-2, and CXCL12 [27,28,29]. This evidence concerns the gene CXCL12 and neoplasm.