Dysregulation of IL-27 concentrations and their correlation with autoimmune parameters have also been shown to relate to the immunopathogenesis of Th1/Th17-mediated inflammatory diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, and Behçet’s disease (BD) [10,11,12,13,14]. Here, IL27 is linked to multiple sclerosis.