The role of IL-27 in the immunopathology of MG has been investigated by a few researchers, in such a way that the effects of IL-27 on naïve T CD4+ cause the response to shift towards TH1 and release IFN-γ, IFN-γ affects APCs (the major cells that produce IL-27) and IL-27 is produced again, creating an inflammatory loop of IL-27/IFN-γ; Also, IL-27 by affecting follicular helper T cells (TFH) in the germinal centers, cause the production of interleukin 21, and IL-21 itself causes the production of autoantibodies against acetylcholine receptors and novel targets as it mentions above [134]. The gene discussed is IL27; the disease is myasthenia gravis.