Additionally, an in vitro asthma study indicated that cyclopamine and GANT61 alleviated the TGFβ1-induced increase in COL1A1 expression, implying that the activation of Hh signaling in asthma is caused, at least in part, by TGF-β, resulting in the airway remodeling [116]. Here, COL1A1 is linked to asthma.