Macrophages are considered to be one of the most important immune cells, mainly due to their innate and acquired immune responses to pathogens and prominent positive role in tissue homeostasis, functioning under the miRNA-21-abundance in tumor-derived extracellular vehicles engulfed by CD14 human monocytes, increasing the expression of M2 markers, and inhibiting that of M1 markers, making it easy to drive the progressive tumor milieu. Here, CD14 is linked to neoplasm.