Saliva’s direct contact with OC lesions makes it a more specific and potentially sensitive screening tool, where >100 salivary biomarkers (DNA, RNA, mRNA, and protein markers) have already been identified, including cytokines (interleukin [IL]-8, IL-1b, and tumor necrosis factor [TNF]-α), defensin-1, p53, Cyfra 21-1, tissue polypeptide-specific antigen, dual specificity phosphatase, spermidine/spermine N1-acetyltransferase, profilin, cofilin-1, and transferrin, which contribute to cancer prevention by removing reactive oxygen species (ROS) generated in the oral cavity [44]. This evidence concerns the gene TNF and cancer.