Firstly, proteins related to the regulation or formation of EVs, such as the up-regulation of GDI1- Ras-related protein Rab-5A, a protein involved in vesicular trafficking and a suspected marker of oral cancer [70], NSF (Vesicle-fusing ATPase), and TMED9 (Transmembrane emp24 domain-containing protein 9), a protein shown to oppose signalling that promotes metastasis in CRC [71]. The gene discussed is TMED9; the disease is colorectal carcinoma.