We also found 12 differentially regulated proteins (i.e., TMED9, NSF, COL6A1, ENO2, DARS1, LRRFIP2, PGM1, GDI1, SLC2A1, IQGAP1, CAMK1, and TSG101) in the cumulative set of CRC stages I, II, and III patients who exhibited tumour recurrence compared to patients with no evidence of recurrence. This evidence concerns the gene ENO2 and neoplasm.