In this case, the recognition of dying tumor cells stimulates the production of cytokines and growth factors such as TNF-alpha (tumor necrosis factor α), EGF, IL-6 in the tumor microenvironment, and these in turn can serve as external anti-apoptotic signals (many tumors show a deficiency in apoptotic cell death) or generally can be directed against different types of cell death, which in turn reduces the efficacy of the applied therapy [79,80]. The gene discussed is TNF; the disease is neoplasm.