Potentially actionable molecular alterations include agnostic targets (NTRK1-2-3 [15], RET fusions [28], BRAF V600E mutations [29], microsatellite instability [30], high tumor mutational burden [31]), or tissue-specific targets, such as EGFR mutation in NSCLC [18] or PIK3CA mutations in breast cancer [32]. The gene discussed is PIK3CA; the disease is breast cancer.